Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | NEK4 | P51957 | 1/20 | 0.42 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729984 | 0.92 | ROCK2 (0.46) | ROCK2MAPTUSP2CYP1A2CYP3A4 | |
| SCHEMBL4798787 | 0.91 | ROCK2 (0.46) | EGFRITKROCK2MAPTUSP2 | |
| SCHEMBL4780062 | 0.90 | EGFR (0.42) | EGFRITKROCK2MAPTUSP2 | |
| SCHEMBL3794472 | 0.89 | ABCG2 (0.56) | EGFRITKROCK2MAPTROCK1 | |
| SCHEMBL4779942 | 0.86 | CLK4 (0.44) | EGFRITKROCK2MAPTUSP2 | |
| SCHEMBL877136 | 0.86 | ROCK2 (0.48) | EGFRITKROCK2MAPTROCK1 | |
| SCHEMBL4784662 | 0.84 | EGFR (0.43) | EGFRITKROCK2MAPTUSP2 | |
| SCHEMBL876780 | 0.83 | MEN1 (0.49) | ROCK2MAPTABCG2MEN1KMT2A | |
| SCHEMBL1729220 | 0.82 | MEN1 (0.44) | EGFRROCK2MAPTUSP2CYP1A2 | |
| SCHEMBL877337 | 0.82 | ROCK2 (0.62) | EGFRITKROCK2MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |