Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | NEK4 | P51957 | 1/20 | 0.41 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1724776 | 0.91 | ROCK2 (0.44) | EGFRROCK2SYKABCG2ERBB2 | |
| SCHEMBL877936 | 0.91 | ROCK2 (0.47) | EGFRITKROCK2ROCK1SYK | |
| SCHEMBL877064 | 0.91 | ROCK2 (0.51) | EGFRITKROCK2ROCK1SYK | |
| SCHEMBL878170 | 0.89 | EGFR (0.47) | EGFRITKROCK2ROCK1SYK | |
| SCHEMBL877114 | 0.88 | ABCG2 (0.45) | EGFRITKROCK2ROCK1SYK | |
| SCHEMBL4779942 | 0.87 | CLK4 (0.44) | EGFRITKROCK2ROCK1SYK | |
| SCHEMBL877115 | 0.86 | ABCG2 (0.47) | EGFRITKROCK2ROCK1EEF2K | |
| SCHEMBL877216 | 0.85 | ABCG2 (0.53) | ABCG2ABCB1 | |
| SCHEMBL3793329 | 0.85 | ABCG2 (0.54) | EGFRITKROCK2SYKABCG2 | |
| SCHEMBL877259 | 0.84 | EGFR (0.45) | EGFRITKROCK2ROCK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040499-A2 | METABOLIC INHIBITORS | SURFACE LOGIX, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |