Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.37 |
| ▸ | BRAF | P15056 | 7/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781871 | 0.90 | MAPK14 (0.37) | MAPK14BRAFCNR1 | |
| SCHEMBL4902142 | 0.87 | BRAF (0.48) | MAPK14BRAF | |
| SCHEMBL4782271 | 0.86 | MAPK14 (0.39) | MAPK14BRAFNR1I2 | |
| SCHEMBL4781875 | 0.86 | SCN10A (0.34) | MAPK14BRAFKDM4EALDH1A1CNR1 | |
| SCHEMBL4782863 | 0.84 | NR1I2 (0.40) | MAPK14BRAFCNR1NR1I2 | |
| SCHEMBL4783254 | 0.78 | MAPK14 (0.35) | MAPK14 | |
| SCHEMBL4780817 | 0.77 | NR1I2 (0.36) | CNR1NR1I2 | |
| SCHEMBL4467266 | 0.77 | MAPK14 (0.41) | MAPK14BRAF | |
| SCHEMBL1378709 | 0.75 | MAPK14 (0.39) | MAPK14BRAF | |
| SCHEMBL4783260 | 0.74 | MAPK14 (0.31) | MAPK14BRAFNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |