SCHEMBL4780685

SCHEMBL4780685

CCCCN1c2ccccc2Sc2ccc(Cl)c(O)c21

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 4/20 0.50
CYP2D6 P10635 6/20 0.46
CYP2C19 P33261 6/20 0.46
PDF Q9HBH1 2/20 0.46
CYP1A2 P05177 5/20 0.45
MAPT P10636 5/20 0.45
HTR1A P08908 4/20 0.45
DRD2 P14416 4/20 0.45
LMNA P02545 4/20 0.45
SMN1; SMN2 Q16637 4/20 0.45
SLC22A1 O15245 3/20 0.45
TP53 P04637 3/20 0.45
CHRM2 P08172 3/20 0.45
CHRM4 P08173 3/20 0.45
CHRM5 P08912 3/20 0.45
ADRA2A P08913 3/20 0.45
CHRM1 P11229 3/20 0.45
ADRA2B P18089 3/20 0.45
ADRA2C P18825 3/20 0.45
CHRM3 P20309 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4778428 0.96 PDF (0.47) KDM1ACYP2D6CYP2C19PDFCYP1A2
SCHEMBL4780730 0.92 CYP2D6 (0.45) KDM1ACYP2D6CYP2C19PDFCYP1A2
SCHEMBL6863955 0.87 CYP2D6 (0.44) KDM1ACYP2D6CYP2C19CYP1A2MAPT
SCHEMBL21436166 0.86 CYP2D6 (0.44) KDM1ACYP2D6CYP2C19CYP1A2MAPT
SCHEMBL7585294 0.86 CYP2D6 (0.65) KDM1ACYP2D6CYP2C19CYP1A2MAPT
SCHEMBL21436165 0.86 PIM1 (0.46) KDM1ACYP2D6CYP2C19CYP1A2MAPT
SCHEMBL4238190 0.83 KDM1A (0.67) KDM1ACYP2D6CYP2C19CYP1A2MAPT
SCHEMBL4783514 0.80 KDM1A (0.45) KDM1ACYP2D6CYP2C19CYP1A2MAPT
SCHEMBL30628542 0.79 KDM1A (0.73) KDM1ACYP2D6CYP2C19PDFCYP1A2
SCHEMBL7998997 0.79 KDM1A (0.73) KDM1ACYP2D6CYP2C19PDFCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008021745-A2 HEPATITIS C VIRUS ENTRY INHIBITORS ITHERX PHARMACEUTICALS, INC. (US) 2008-02-21 WO disclosed