Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.43 |
| ▸ | DRD1 | P21728 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780685 | 0.86 | KDM1A (0.50) | CYP2D6CYP2C19HTR1ACYP1A2DRD2 | |
| SCHEMBL4778428 | 0.85 | PDF (0.47) | CYP2D6CYP2C19HTR1ACYP1A2DRD2 | |
| SCHEMBL6863955 | 0.84 | CYP2D6 (0.44) | CYP2D6CYP2C19HTR1ACYP1A2DRD2 | |
| SCHEMBL4780730 | 0.84 | CYP2D6 (0.45) | CYP2D6CYP2C19PTGS1PTGS2HTR1A | |
| SCHEMBL7585294 | 0.83 | CYP2D6 (0.65) | CYP2D6CYP2C19HTR1ACYP1A2DRD2 | |
| SCHEMBL21436165 | 0.83 | PIM1 (0.46) | CYP2D6CYP2C19HTR1ACYP1A2DRD2 | |
| SCHEMBL4238190 | 0.81 | KDM1A (0.67) | CYP2D6CYP2C19PTGS1HTR1ACYP1A2 | |
| SCHEMBL4783514 | 0.79 | KDM1A (0.45) | CYP2D6CYP2C19HTR1ACYP1A2DRD2 | |
| SCHEMBL21977447 | 0.78 | LMNA (0.69) | CYP2D6CYP2C19HTR1ACYP1A2DRD2 | |
| SCHEMBL15423268 | 0.76 | PIM1 (0.63) | CYP2D6CYP2C19PTGS1PTGS2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002335-A1 | SMALL MOLECULE ENHANCEMENT OF 20S PROTEASOME ACTIVITY TARGETS INTRINSICALLY DISORDERED PROTEINS | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2023-01-05 | — | — | US | disclosed |
| WO-2018226589-A9 | SMALL MOLECULE PROTEOSOME ACTIVATORS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2019-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002335-A1 | SMALL MOLECULE ENHANCEMENT OF 20S PROTEASOME ACTIVITY TARGETS INTRINSICALLY DISORDERED PROTEINS | PSMG3, PSME3, PSME1 | CYP2D6 3919/4885CYP2C19 4626/4885PTGS1 3937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.