Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.65 |
| ▸ | HTR1A | P08908 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.65 |
| ▸ | DRD1 | P21728 | 4/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.65 |
| ▸ | DRD3 | P35462 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.65 |
| ▸ | THPO | P40225 | 4/20 | 0.65 |
| ▸ | MTOR | P42345 | 4/20 | 0.65 |
| ▸ | KDM1A | O60341 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780685 | 0.86 | KDM1A (0.50) | CYP2D6CYP1A2CYP2C19HTR1ATP53 | |
| SCHEMBL4778428 | 0.85 | PDF (0.47) | CYP2D6CYP1A2CYP2C19HTR1ATP53 | |
| SCHEMBL6863955 | 0.84 | CYP2D6 (0.44) | CYP2D6CYP1A2CYP2C19HTR1ATP53 | |
| SCHEMBL4780730 | 0.84 | CYP2D6 (0.45) | CYP2D6CYP1A2CYP2C19HTR1ATP53 | |
| SCHEMBL21436166 | 0.83 | CYP2D6 (0.44) | CYP2D6CYP1A2CYP2C19HTR1ATP53 | |
| SCHEMBL21436165 | 0.83 | PIM1 (0.46) | CYP2D6CYP1A2CYP2C19HTR1ATP53 | |
| SCHEMBL11197295 | 0.83 | CYP2D6 (0.61) | CYP2D6CYP1A2CYP2C19HTR1ATP53 | |
| SCHEMBL7067788 | 0.83 | CYP2D6 (0.72) | CYP2D6CYP1A2CYP2C19HTR1ATP53 | |
| SCHEMBL4238190 | 0.81 | KDM1A (0.67) | CYP2D6CYP1A2CYP2C19HTR1ATP53 | |
| Promazine SCHEMBL9052694 | 0.80 | CYP2D6 (1.00) | CYP2D6CYP1A2CYP2C19HTR1ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222204-A1 | A DNA MOLECULE ENCODING A VARIANT $g(a) 2B?-ADRENOCEPTOR PROTEIN, AND USES THEREOF | Oy Juvantia Pharma Ltd (FI) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001029082-A1 | A DNA MOLECULE ENCODING A VARIANT α2B-ADRENOCEPTOR PROTEIN, AND USES THEREOF | OY JUVANTIA PHARMA LTD (FI) | 2001-04-26 | — | — | WO | disclosed |