Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 12/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RPS27 | P42677 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773204 | 0.86 | CHEK2 (0.38) | CHEK2RPS27MAPK8PDE10A | |
| SCHEMBL4779864 | 0.75 | NOX1 (0.41) | PDE10AKDM4E | |
| SCHEMBL4778982 | 0.69 | PSEN1 (0.36) | KDM4E | |
| SCHEMBL4879715 | 0.68 | PIM1 (0.44) | L3MBTL1KDM4EGAA | |
| SCHEMBL4776292 | 0.68 | PDE10A (0.38) | L3MBTL1PDE10AKDM4E | |
| SCHEMBL2879121 | 0.67 | PARP10 (0.38) | L3MBTL1RPS27MAPK8KDM4EGAA | |
| SCHEMBL8590356 | 0.65 | TUBB4A (0.48) | CHEK2L3MBTL1KDM4EGAA | |
| SCHEMBL23224123 | 0.63 | F2 (0.44) | L3MBTL1KDM4EPARP15PARP10PARP2 | |
| SCHEMBL2762402 | 0.63 | PARP10 (0.66) | L3MBTL1KDM4EPARP15PARP10PARP2 | |
| SCHEMBL10191575 | 0.63 | KIT (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979315-A2 | METHODS FOR TREATING HEPATITIS C | PTC Therapeutics, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007084435-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |