Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | CDC25C | P30307 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773901 | 0.79 | KCNQ2 (0.41) | PDE10AHSD17B10MAPTALDH1A1KDM4E | |
| SCHEMBL4779864 | 0.74 | NOX1 (0.41) | PDE10AMAPTESR2PDE9AALDH1A1 | |
| SCHEMBL4778982 | 0.72 | PSEN1 (0.36) | HSD17B10MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL4774067 | 0.71 | RXRA (0.44) | MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL4773204 | 0.68 | CHEK2 (0.38) | PDE10A | |
| SCHEMBL4879715 | 0.67 | PIM1 (0.44) | ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL4775583 | 0.66 | PDE10A (0.35) | PDE10AHSD17B10MAPTPDE3AALDH1A1 | |
| SCHEMBL12966379 | 0.66 | MAPT (0.50) | MAPTALDH1A1KDM4EHPGDTP53 | |
| SCHEMBL1253383 | 0.64 | PDE3A (0.37) | HSD17B10MAPTPDE3AALDH1A1KDM4E | |
| SCHEMBL1427328 | 0.64 | KDM4E (0.36) | HSD17B10MAPTALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984332-A2 | METHODS FOR TREATING HEPATITIS C | PTC Therapeutics, Inc. (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084413-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |