Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780831 | 0.91 | TNK2 (0.39) | ACKR3TNK2GLSDHODHKMT2A | |
| SCHEMBL4782951 | 0.86 | BRAF (0.37) | KMT2AWDR5BRAF | |
| SCHEMBL4779984 | 0.86 | ACKR3 (0.41) | ACKR3TNK2GLSHPGDALDH1A1 | |
| SCHEMBL4781496 | 0.85 | ACKR3 (0.40) | ACKR3TNK2GLSKMT2AHPGD | |
| SCHEMBL4783075 | 0.83 | PLAU (0.42) | ACKR3BRAF | |
| SCHEMBL4783406 | 0.82 | RXFP1 (0.40) | DHODHALDH1A1 | |
| SCHEMBL4783684 | 0.82 | ACKR3 (0.40) | ACKR3GLSKMT2AHPGDALDH1A1 | |
| SCHEMBL4781500 | 0.82 | PLAU (0.41) | ACKR3BRAF | |
| SCHEMBL4936382 | 0.79 | HPGD (0.41) | ACKR3GLSDHODHHPGDALDH1A1 | |
| SCHEMBL4783689 | 0.79 | ACKR3 (0.39) | ACKR3DHODHKMT2AHPGDBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |