Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 9/20 | 0.38 |
| ▸ | RAF1 | P04049 | 6/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783684 | 0.91 | ACKR3 (0.40) | ACKR3BRAFFASNUSP30EGLN1 | |
| SCHEMBL4783075 | 0.90 | PLAU (0.42) | ACKR3BRAFRAF1 | |
| SCHEMBL4781500 | 0.88 | PLAU (0.41) | ACKR3BRAFRAF1 | |
| SCHEMBL4782957 | 0.87 | BRAF (0.42) | ACKR3BRAFFASNEGLN1NAMPT | |
| SCHEMBL4936382 | 0.86 | HPGD (0.41) | ACKR3BRAFNAMPTHPGDDHODH | |
| SCHEMBL4779984 | 0.82 | ACKR3 (0.41) | ACKR3BRAFHPGD | |
| SCHEMBL4780831 | 0.82 | TNK2 (0.39) | ACKR3BRAFRAF1KMT2ADHODH | |
| SCHEMBL4778221 | 0.81 | RAF1 (0.43) | BRAFRAF1 | |
| SCHEMBL4781496 | 0.81 | ACKR3 (0.40) | ACKR3BRAFHPGDKMT2A | |
| SCHEMBL4905087 | 0.80 | DHODH (0.36) | BRAFRAF1FASNHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |