Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 11/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4993095 | 0.88 | METAP2 (0.39) | PSMB5ENPP2METAP2LMNAPTGDR2 | |
| SCHEMBL4990060 | 0.88 | ALDH1A1 (0.41) | PSMB5ENPP2METAP2LMNAPTGDR2 | |
| SCHEMBL4999246 | 0.87 | METAP2 (0.42) | ENPP2METAP2LMNAPTGDR2NPC1 | |
| SCHEMBL4996876 | 0.86 | KEAP1 (0.43) | PSMB5ENPP2RXRARXRBRXRG | |
| SCHEMBL4995223 | 0.86 | ALDH1A1 (0.47) | ENPP2LMNAPTGDR2NPC1KMT2A | |
| SCHEMBL4725811 | 0.85 | KMT2A (0.38) | PSMB5ENPP2METAP2LMNAPTGDR2 | |
| SCHEMBL4996913 | 0.84 | ALDH1A1 (0.41) | PSMB5ENPP2LMNANPC1KMT2A | |
| SCHEMBL14092541 | 0.83 | KMT2A (0.42) | PSMB5ENPP2METAP2LMNAPTGDR2 | |
| SCHEMBL14092521 | 0.83 | MAPT (0.39) | ENPP2METAP2LMNAPTGDR2NPC1 | |
| SCHEMBL14092498 | 0.83 | KEAP1 (0.42) | ENPP2METAP2LMNAPTGDR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016676-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |