Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.42 |
| ▸ | CA2 | P00918 | 6/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | CA4 | P22748 | 3/20 | 0.42 |
| ▸ | CA3 | P07451 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923293 | 0.83 | CA12 (0.53) | CA1CA2CA12CA9CA4 | |
| SCHEMBL2408402 | 0.78 | L3MBTL1 (0.46) | CA1CA2CA12CA9CA4 | |
| SCHEMBL8169096 | 0.78 | ALDH1A1 (0.45) | CA1CA2CA12CA9CA3 | |
| SCHEMBL10906258 | 0.78 | CA1 (0.49) | CA1CA2CA12CA9PTGES2 | |
| SCHEMBL1479996 | 0.77 | ALDH1A1 (0.59) | CA1CA2CA12CA9KDM4E | |
| SCHEMBL30925348 | 0.77 | PTGES2 (0.45) | CA1CA2CA12CA9CA4 | |
| SCHEMBL7200194 | 0.77 | PTGES2 (0.36) | CA1CA2CA12CA9CA7 | |
| SCHEMBL8296088 | 0.76 | PDIA6 (0.51) | CA1CA2CA12CA9CA4 | |
| SCHEMBL31501416 | 0.76 | PDIA6 (0.51) | CA1CA2CA12CA9CA4 | |
| SCHEMBL29587590 | 0.75 | CA1 (0.53) | CA1CA2CA12CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |