Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 5/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781060 | 0.88 | NCEH1 (0.40) | NCEH1PTPN1ALDH1A1MAPK1PDE5A | |
| SCHEMBL4783542 | 0.80 | NCEH1 (0.41) | NCEH1PTPN1MAPK1MAPTNPC1 | |
| SCHEMBL4783722 | 0.79 | NCEH1 (0.40) | NCEH1PTPN1MAPK1MAPTLMNA | |
| SCHEMBL4785214 | 0.78 | NCEH1 (0.38) | NCEH1ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL4672473 | 0.77 | PTPN1 (0.51) | NCEH1PTPN1 | |
| SCHEMBL4675977 | 0.77 | PTPN1 (0.49) | NCEH1PTPN1MAPTNPC1RAB9A | |
| SCHEMBL4674024 | 0.76 | PTPN1 (0.43) | NCEH1PTPN1MAPTNPC1RAB9A | |
| SCHEMBL4673192 | 0.76 | PTPN1 (0.43) | NCEH1PTPN1MAPTGAALMNA | |
| SCHEMBL4675976 | 0.76 | PTPN1 (0.39) | NCEH1PTPN1MAPTNPC1RAB9A | |
| SCHEMBL3970085 | 0.72 | ALDH1A1 (0.44) | ALDH1A1MAPK1MAPK14MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |