Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 10/20 | 0.58 |
| ▸ | HTR2C | P28335 | 4/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.50 |
| ▸ | RBP4 | P02753 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781253 | 0.89 | HTR2A (0.61) | PTGS1PTGS2HTR2AHTR2CTMEM97 | |
| SCHEMBL4782758 | 0.84 | HTR2A (0.60) | PTGS1PTGS2HTR2AHTR2CRBP4 | |
| SCHEMBL4783543 | 0.78 | HTR2A (0.58) | PTGS1PTGS2HTR2AHTR2CDRD2 | |
| SCHEMBL4848833 | 0.78 | HTR2A (0.63) | PTGS1PTGS2HTR2AHTR2CRBP4 | |
| SCHEMBL4780625 | 0.78 | HTR2A (0.64) | PTGS1PTGS2HTR2AHTR2CRBP4 | |
| SCHEMBL4783828 | 0.77 | HTR2A (0.62) | HTR2AHTR2CTMEM97DRD2MEN1 | |
| SCHEMBL4782359 | 0.77 | NPC1 (0.57) | HTR2AHTR2CTMEM97RBP4DRD2 | |
| SCHEMBL5099895 | 0.76 | HTR2A (0.55) | PTGS1PTGS2HTR2AHTR2CTMEM97 | |
| SCHEMBL22825349 | 0.75 | HTR2A (0.76) | HTR2AHTR2CTMEM97PRKAA2KCNH2 | |
| SCHEMBL3135392 | 0.75 | HTR2A (0.71) | HTR2AHTR2CTMEM97PRKAA2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |