Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.52 |
| ▸ | ADK | P55263 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355880 | 0.80 | ADK (0.52) | EGFRADKAURKA | |
| SCHEMBL5348597 | 0.77 | TTBK1 (0.49) | EGFRADK | |
| SCHEMBL5785011 | 0.77 | EGFR (0.54) | EGFR | |
| SCHEMBL5361357 | 0.76 | TTBK1 (0.48) | EGFRADK | |
| Hydrochloric Acid SCHEMBL5350968 | 0.76 | EGFR (0.53) | EGFR | |
| SCHEMBL5353750 | 0.76 | EGFR (0.55) | EGFR | |
| Hydrochloric Acid SCHEMBL5351366 | 0.76 | EGFR (0.53) | EGFR | |
| SCHEMBL14355886 | 0.74 | GSK3B (0.54) | EGFRADKABCG2 | |
| SCHEMBL4783005 | 0.74 | RAB9A (0.44) | EGFRABCG2 | |
| SCHEMBL5358394 | 0.72 | EGFR (0.56) | EGFRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |