Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.36 |
| ▸ | PDE4A | P27815 | 6/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | BMP4 | P12644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780912 | 0.83 | PDE10A (0.47) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL4780878 | 0.82 | MAOB (0.49) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL4780055 | 0.80 | PDE10A (0.50) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL4778874 | 0.78 | TP53 (0.46) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL4781215 | 0.72 | MAOA (0.39) | PRMT5WDR77ROCK2ROCK1 | |
| SCHEMBL4762145 | 0.69 | PDE10A (0.62) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL14303843 | 0.68 | ROCK2 (0.34) | ROCK2ROCK1BMP4 | |
| SCHEMBL4723850 | 0.64 | PDE10A (0.64) | PDE10A | |
| SCHEMBL14310547 | 0.63 | PDE10A (0.51) | PDE10APDE4BPDE4APDE3BPDE3A | |
| SCHEMBL30123360 | 0.62 | PDE10A (0.51) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008001182-A1 | TRICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-01-03 | — | — | WO | claimed |
| EP-4103161-B1 | COMPOSITIONS AND USES THEREOF | BENEVOLENTAI CAMBRIDGE LTD (GB) | 2023-12-20 | — | — | EP | disclosed |
| EP-4103161-A1 | COMPOSITIONS AND USES THEREOF | BenevolentAI Cambridge Limited (GB) | 2022-12-21 | — | — | EP | disclosed |
| CN-115484938-A | Composition and use thereof | 博善人工智能剑桥有限公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2008001182-A1 | TRICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-01-03 | — | — | WO | disclosed |
| WO-2008001182-A1 | TRICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-01-03 | — | — | WO | disclosed |