Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780878 | 0.84 | MAOB (0.49) | SMN1; SMN2RAB9ANPC1PDE10APDE4B | |
| SCHEMBL4780055 | 0.83 | PDE10A (0.50) | PDE10APDE4BPDE3BPDE3APDE4A | |
| SCHEMBL4780912 | 0.83 | PDE10A (0.47) | PDE10APDE4BPDE3BPDE3APDE4A | |
| SCHEMBL4781570 | 0.78 | PDE10A (0.36) | PDE10APDE4BPDE3BPDE3APDE4A | |
| SCHEMBL4763295 | 0.76 | PDE10A (0.61) | RAB9ANPC1PDE10APDE4BPDE3B | |
| SCHEMBL4781215 | 0.73 | MAOA (0.39) | — | |
| SCHEMBL30123040 | 0.72 | RAB9A (0.56) | TP53SMN1; SMN2RAB9ANPC1PDE10A | |
| SCHEMBL4763361 | 0.72 | RAB9A (0.56) | TP53SMN1; SMN2RAB9ANPC1PDE10A | |
| SCHEMBL30123201 | 0.71 | PDE10A (0.60) | TP53SMN1; SMN2RAB9ANPC1PDE10A | |
| SCHEMBL5519473 | 0.71 | PDE10A (0.60) | TP53SMN1; SMN2RAB9ANPC1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4103161-B1 | COMPOSITIONS AND USES THEREOF | BENEVOLENTAI CAMBRIDGE LTD (GB) | 2023-12-20 | — | — | EP | disclosed |
| EP-4103161-A1 | COMPOSITIONS AND USES THEREOF | BenevolentAI Cambridge Limited (GB) | 2022-12-21 | — | — | EP | disclosed |
| CN-115484938-A | Composition and use thereof | 博善人工智能剑桥有限公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2008001182-A1 | TRICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-01-03 | — | — | WO | disclosed |
| WO-2008001182-A1 | TRICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-01-03 | — | — | WO | disclosed |