Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 6/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780707 | 0.93 | NR1I2 (0.36) | ACKR3NR1I2PRKAA2GPR119IRAK4 | |
| SCHEMBL4779570 | 0.92 | SSTR4 (0.40) | ACKR3NR1I2PRKAA2GPR119 | |
| SCHEMBL4781611 | 0.90 | TEK (0.39) | ACKR3NR1I2NPC1RAB9APRKAA2 | |
| SCHEMBL4780817 | 0.86 | NR1I2 (0.36) | NR1I2GPR119CNR2CNR1IRAK4 | |
| SCHEMBL4782033 | 0.86 | NR1I2 (0.35) | NR1I2GPR119IRAK4TYK2STAT3 | |
| SCHEMBL4782188 | 0.84 | MEN1 (0.42) | ACKR3NR1I2 | |
| SCHEMBL4779207 | 0.84 | NR1I2 (0.38) | ACKR3NR1I2GPR119CNR2IRAK4 | |
| SCHEMBL4780719 | 0.83 | TEK (0.39) | ACKR3NR1I2PRKAA2GPR119 | |
| SCHEMBL4781558 | 0.83 | GLS (0.41) | ACKR3NPC1RAB9AGLSSMN1; SMN2 | |
| SCHEMBL4783140 | 0.82 | MAPK14 (0.36) | NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |