SCHEMBL4781635

SCHEMBL4781635

O=C(O)c1cc(Cl)c2ccccc2c1C(=O)O

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.68
KDM4E B2RXH2 4/20 0.68
HPGD P15428 3/20 0.68
KMT2A Q03164 3/20 0.68
HSD17B10 Q99714 3/20 0.68
MEN1 O00255 2/20 0.68
MAPT P10636 1/20 0.68
PKM P14618 1/20 0.68
HTT P42858 1/20 0.68
CYP1A2 P05177 1/20 0.47
GLA P06280 1/20 0.47
CYP2C19 P33261 1/20 0.47
PBRM1 Q86U86 1/20 0.44
AKR1C2 P52895 1/20 0.43
AKR1C1 Q04828 1/20 0.43
TSHR P16473 3/20 0.43
ATM Q13315 1/20 0.43
THRB P10828 1/20 0.43
ALOX15 P16050 1/20 0.43
CYP2C9 P11712 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11664708 0.83 KMT2A (0.53) ALDH1A1KDM4EHPGDKMT2AHSD17B10
SCHEMBL31401764 0.82 HPGD (0.57) ALDH1A1KDM4EHPGDKMT2AHSD17B10
SCHEMBL29511 0.82 HPGD (0.57) ALDH1A1KDM4EHPGDKMT2AHSD17B10
SCHEMBL29417867 0.82 HPGD (0.57) ALDH1A1KDM4EHPGDKMT2AHSD17B10
SCHEMBL11419997 0.81 ALDH1A1 (0.50) ALDH1A1KDM4EHPGDKMT2AHSD17B10
SCHEMBL485443 0.81 HSD17B10 (1.00) ALDH1A1KDM4EHPGDKMT2AHSD17B10
SCHEMBL4781541 0.78 THRB (0.69) ALDH1A1KDM4EHPGDKMT2AHSD17B10
SCHEMBL10940566 0.77 IDO1 (0.48) ALDH1A1KDM4EHPGDKMT2AHSD17B10
SCHEMBL9996096 0.77 PRNP (0.54) ALDH1A1KDM4EHPGDKMT2AHSD17B10
SCHEMBL5337894 0.77 ALDH1A1 (0.50) ALDH1A1KDM4EHPGDKMT2AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-58029741-A None JP disclosed
JP-52151152-A None JP disclosed
WO-2008001036-A2 COMPOUND, COMPOSITION AND USE FUJIFILM IMAGING COLORANTS LIMITED (GB) 2008-01-03 WO disclosed
EP-0656566-B1 Electrophotographic photoreceptor MITSUBISHI CHEM CORP (JP) 1999-01-20 EP disclosed
US-5547791-A CONTAINING ARYLAMINE HYDROZONE COMPOUND MITSUBISHI CHEMICAL CORPORATION (JP) 1996-08-20 US disclosed
EP-0656566-A1 Electrophotographic photoreceptor Mitsubishi Chemical Corporation (JP) 1995-06-07 EP disclosed
EP-0506088-A2 Water soluble copolymers prepared from vinyl functional monomers UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1992-09-30 EP disclosed
JP-S5829741-A NOVEL CHLORINATION OF NAPHTHALIC ACID NIPPON KAGAKU KOGYOSHO:KK 1983-02-22 JP disclosed
US-4212813-A OXIDIZING ACENAPHTHENES, COBALT COMPOUND CATALYST NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1980-07-15 US disclosed
JP-S52151152-A PREPARATION OF 4-CHLORONAPHTHALIC ACID OR ITS ANHYDRIDE NIPPON KAYAKU CO LTD 1977-12-15 JP disclosed
US-3954810-A Process for the preparation of 4-bromonaphthalic acid anhydride HOECHST AKTIENGESELLSCHAFT (DT) 1976-05-04 US disclosed