SCHEMBL11664708

SCHEMBL11664708

O=C(OBr)c1cc(Cl)c2ccccc2c1C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.53
KDM4E B2RXH2 5/20 0.53
ALDH1A1 P00352 4/20 0.53
MEN1 O00255 4/20 0.53
HPGD P15428 2/20 0.53
HSD17B10 Q99714 2/20 0.53
MAPT P10636 2/20 0.53
PKM P14618 1/20 0.53
HTT P42858 1/20 0.53
CYP1A2 P05177 2/20 0.40
CYP2C19 P33261 2/20 0.40
GLA P06280 1/20 0.40
ATM Q13315 1/20 0.37
SLC26A4 O43511 1/20 0.36
PBRM1 Q86U86 1/20 0.35
DRD2 P14416 1/20 0.34
DRD3 P35462 1/20 0.34
AKR1C2 P52895 1/20 0.34
AKR1C1 Q04828 1/20 0.34
GPR35 Q9HC97 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4781635 0.83 ALDH1A1 (0.68) KMT2AKDM4EALDH1A1MEN1HPGD
SCHEMBL11667920 0.74 KMT2A (0.54) KMT2AKDM4EALDH1A1MEN1HPGD
SCHEMBL10909546 0.71 CDC25B (0.53) KMT2AKDM4EALDH1A1MEN1HPGD
SCHEMBL27861348 0.70 CES2 (0.58) KMT2AALDH1A1MEN1HPGDMAPT
SCHEMBL485443 0.69 HSD17B10 (1.00) KMT2AKDM4EALDH1A1MEN1HPGD
SCHEMBL28264517 0.69 KDM4E (0.46) KDM4EALDH1A1MAPTHTTPOLB
SCHEMBL27872643 0.68 KMT2A (0.59) KMT2AKDM4EALDH1A1MEN1HPGD
SCHEMBL27951905 0.68 ALDH1A1 (0.64) KDM4EALDH1A1HPGDHSD17B10MAPT
SCHEMBL8967049 0.68 ALDH1A1 (0.60) KMT2AKDM4EALDH1A1MEN1HPGD
SCHEMBL11419997 0.67 ALDH1A1 (0.50) KMT2AKDM4EALDH1A1MEN1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4077960-A YELLOW, POLYMERS TEIJIN LIMITED (JA) 1978-03-07 US disclosed