SCHEMBL4781702

SCHEMBL4781702

O=Cc1c(Cl)c(Cl)cn1-c1ccccn1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.40
POLB P06746 2/20 0.38
KDM4E B2RXH2 5/20 0.38
TSHR P16473 2/20 0.38
GAA P10253 2/20 0.36
ALDH1A1 P00352 4/20 0.36
HSD17B10 Q99714 3/20 0.36
HTT P42858 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HPGD P15428 2/20 0.36
PTK2 Q05397 1/20 0.36
P2RX7 Q99572 2/20 0.35
EP300 Q09472 1/20 0.35
KAT2B Q92831 1/20 0.35
CD274 Q9NZQ7 2/20 0.34
ALKBH2 Q6NS38 1/20 0.34
EGLN1 Q9GZT9 1/20 0.34
KMT2A Q03164 1/20 0.34
PDCD1 Q15116 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27727907 0.79 PTK2 (0.42) SMN1; SMN2POLBKDM4ETSHRGAA
SCHEMBL4784077 0.78 HTT (0.35) SMN1; SMN2ALDH1A1HTTTDP1KMT2A
SCHEMBL951410 0.73 SMN1; SMN2 (0.41) SMN1; SMN2KDM4ETSHRALDH1A1HSD17B10
SCHEMBL28554146 0.70 GAA (0.50) SMN1; SMN2POLBKDM4ETSHRGAA
SCHEMBL8539865 0.69 POLB (0.49) SMN1; SMN2POLBKDM4ETSHRGAA
SCHEMBL29728434 0.67 ATM (0.55) SMN1; SMN2POLBKDM4ETSHRGAA
SCHEMBL951470 0.67 ATM (0.55) SMN1; SMN2POLBKDM4ETSHRGAA
SCHEMBL28468058 0.66 PTK2 (0.44) SMN1; SMN2POLBKDM4ETSHRGAA
SCHEMBL31596091 0.66 SMN1; SMN2 (0.40) SMN1; SMN2POLBKDM4EALDH1A1HSD17B10
SCHEMBL951430 0.66 CD274 (0.39) SMN1; SMN2KDM4ETSHRALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed