SCHEMBL4784077

SCHEMBL4784077

O=Cc1c(Cl)c(Cl)cn1-c1ncccc1Cl

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HSD11B1 P28845 1/20 0.35
TRPA1 O75762 2/20 0.33
MALT1 Q9UDY8 1/20 0.33
NFE2L2 Q16236 4/20 0.33
TRPV1 Q8NER1 1/20 0.33
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
KMT2A Q03164 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
RPS6KA5 O75582 1/20 0.32
TRIM24 O15164 1/20 0.32
TRIM33 Q9UPN9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4782203 0.81 TRIM24 (0.36) HTTSMN1; SMN2HSD11B1TRPA1MALT1
SCHEMBL27727896 0.79 RPS6KA5 (0.38) HTTSMN1; SMN2HSD11B1TRPA1MALT1
SCHEMBL4781702 0.78 SMN1; SMN2 (0.40) HTTSMN1; SMN2ALDH1A1KMT2ATDP1
SCHEMBL27727985 0.76 RPS6KA5 (0.37) HTTSMN1; SMN2HSD11B1TRPA1MALT1
SCHEMBL950203 0.74 TRPA1 (0.36) HTTSMN1; SMN2HSD11B1TRPA1MALT1
SCHEMBL950454 0.73 ALDH1A1 (0.46) HSD11B1ALDH1A1RPS6KA5TRIM24TRIM33
SCHEMBL950752 0.72 ALDH1A1 (0.36) HTTSMN1; SMN2HSD11B1TRPA1MALT1
SCHEMBL950762 0.72 TRPV1 (0.33) HTTSMN1; SMN2HSD11B1TRPA1MALT1
SCHEMBL951774 0.67 HSD11B1 (0.35) HTTSMN1; SMN2HSD11B1TRPA1MALT1
SCHEMBL8500406 0.66 RPS6KA5 (0.40) HSD11B1TRPA1MALT1TRPV1RPS6KA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed