Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.34 |
| ▸ | BRAF | P15056 | 12/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.34 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.34 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | POLQ | O75417 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784063 | 0.91 | RAF1 (0.36) | RAF1BRAFABCB1POLQ | |
| SCHEMBL4844549 | 0.90 | RAF1 (0.34) | RAF1BRAFABCB1 | |
| SCHEMBL4780774 | 0.88 | TRPV1 (0.34) | RAF1BRAFABCB1 | |
| SCHEMBL4780489 | 0.87 | ABL1 (0.40) | RAF1BRAFABCB1 | |
| SCHEMBL4780311 | 0.82 | KDM4E (0.38) | RAF1BRAF | |
| SCHEMBL4781974 | 0.81 | PSEN1 (0.39) | RAF1BRAFMAPK14POLQ | |
| SCHEMBL4780832 | 0.79 | LMNA (0.42) | RAF1BRAF | |
| SCHEMBL4726702 | 0.79 | PTPN1 (0.38) | RAF1BRAFMAPK14EPHA3FRK | |
| SCHEMBL14293721 | 0.77 | POLQ (0.34) | RAF1BRAFPOLQ | |
| SCHEMBL4728030 | 0.77 | MAPK14 (0.42) | RAF1BRAFMAPK14POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |