Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 18/20 | 0.36 |
| ▸ | BRAF | P15056 | 18/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4844549 | 0.92 | RAF1 (0.34) | RAF1BRAFABCB1 | |
| SCHEMBL4780774 | 0.92 | TRPV1 (0.34) | RAF1BRAFABCB1 | |
| SCHEMBL4781741 | 0.91 | RAF1 (0.34) | RAF1BRAFABCB1POLQ | |
| SCHEMBL4780489 | 0.91 | ABL1 (0.40) | RAF1BRAFABCB1 | |
| SCHEMBL4780311 | 0.86 | KDM4E (0.38) | RAF1BRAF | |
| SCHEMBL4781974 | 0.85 | PSEN1 (0.39) | RAF1BRAFPOLQ | |
| SCHEMBL4780832 | 0.83 | LMNA (0.42) | RAF1BRAF | |
| SCHEMBL4726702 | 0.83 | PTPN1 (0.38) | RAF1BRAFPOLQ | |
| SCHEMBL14293721 | 0.81 | POLQ (0.34) | RAF1BRAFPOLQ | |
| SCHEMBL4728030 | 0.81 | MAPK14 (0.42) | RAF1BRAFPOLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |