Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | RAF1 | P04049 | 12/20 | 0.37 |
| ▸ | BRAF | P15056 | 12/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781974 | 0.89 | PSEN1 (0.39) | RAF1BRAF | |
| SCHEMBL4780311 | 0.87 | KDM4E (0.38) | RAF1BRAFALDH1A1MAPT | |
| SCHEMBL4726702 | 0.84 | PTPN1 (0.38) | RAF1BRAFMAPT | |
| SCHEMBL4784063 | 0.83 | RAF1 (0.36) | RAF1BRAF | |
| SCHEMBL14293721 | 0.82 | POLQ (0.34) | RAF1BRAF | |
| SCHEMBL4783723 | 0.82 | LMNA (0.35) | LMNACYP3A4ABL1ALDH1A1MAPT | |
| SCHEMBL4728030 | 0.82 | MAPK14 (0.42) | RAF1BRAFMAPT | |
| SCHEMBL4730567 | 0.81 | TRPV1 (0.40) | LMNACYP3A4RAF1BRAFALDH1A1 | |
| SCHEMBL4780774 | 0.81 | TRPV1 (0.34) | RAF1BRAF | |
| SCHEMBL4725075 | 0.80 | F7 (0.35) | RAF1BRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |