Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 17/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782631 | 1.00 | HTR1A (0.50) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4781412 | 0.98 | HTR1A (0.51) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4783147 | 0.98 | HTR1A (0.51) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4783317 | 0.94 | HTR1A (0.50) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4783988 | 0.94 | HTR1A (0.50) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4900902 | 0.93 | HTR1A (0.49) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4898253 | 0.93 | HTR1A (0.49) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4877084 | 0.92 | HTR1A (0.51) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4781308 | 0.92 | HTR1A (0.51) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4898071 | 0.87 | HTR1A (0.49) | HTR1ADRD2CYP3A4CYP2C8DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139546-A1 | Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines | WYETH (US) | 2008-06-12 | — | — | US | claimed |
| US-20080139546-A1 | Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines | WYETH (US) | 2008-06-12 | — | — | US | disclosed |
| WO-2008042735-A1 | TETRAHYDROQUINOLINE, INDOLINE, AND RELATED ANILINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH (US) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139546-A1 | Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines | HTR5A, HTR2C, HTR3A | HTR1A 6/4885DRD2 33/4885CYP3A4 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.