Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 2/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4795831 | 0.89 | SLC40A1 (0.55) | SLC40A1CLK1MEN1KMT2AGAA | |
| SCHEMBL3078414 | 0.87 | SLC40A1 (0.57) | SLC40A1CLK1MEN1KMT2AGAA | |
| SCHEMBL31478924 | 0.87 | SLC40A1 (0.57) | SLC40A1CLK1MEN1KMT2AGAA | |
| SCHEMBL4781821 | 0.86 | SLC40A1 (0.49) | SLC40A1CLK1MEN1KMT2AGAA | |
| SCHEMBL4777395 | 0.86 | AXL (0.54) | SLC40A1CLK1MEN1KMT2AGAA | |
| SCHEMBL30304828 | 0.85 | SLC40A1 (0.51) | SLC40A1CLK1MEN1KMT2AGAA | |
| SCHEMBL4778521 | 0.85 | SLC40A1 (0.51) | SLC40A1CLK1MEN1KMT2AGAA | |
| SCHEMBL4781730 | 0.85 | CCR2 (0.53) | SLC40A1CLK1MEN1KMT2AGAA | |
| SCHEMBL4779280 | 0.85 | SLC40A1 (0.51) | SLC40A1CLK1MEN1KMT2AGAA | |
| SCHEMBL4727559 | 0.85 | SLC40A1 (0.51) | SLC40A1CLK1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | claimed |
| WO-2008008374-A2 | CCR2 INHIBITORS AND METHODS OF USE THEREOF | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |