Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 6/20 | 0.38 |
| ▸ | HTR6 | P50406 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | WNT3 | P56703 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781473 | 0.84 | SFRP1 (0.46) | SFRP1HTR6WNT3 | |
| SCHEMBL4781306 | 0.82 | SFRP1 (0.46) | SFRP1HTR6WNT3 | |
| SCHEMBL4780921 | 0.82 | SFRP1 (0.48) | SFRP1HTR6WNT3 | |
| SCHEMBL4783287 | 0.80 | HTR6 (0.47) | SFRP1HTR6WNT3 | |
| SCHEMBL4783281 | 0.80 | HTR6 (0.47) | SFRP1HTR6WNT3 | |
| SCHEMBL4784256 | 0.80 | SFRP1 (0.46) | SFRP1HTR6WNT3 | |
| SCHEMBL4782529 | 0.80 | SFRP1 (0.56) | SFRP1HTR6WNT3 | |
| SCHEMBL4783391 | 0.80 | SFRP1 (0.46) | SFRP1HTR6WNT3 | |
| SCHEMBL4783395 | 0.80 | SFRP1 (0.46) | SFRP1HTR6WNT3 | |
| SCHEMBL4786071 | 0.80 | SFRP1 (0.43) | SFRP1HTR6WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |