SCHEMBL4782011

SCHEMBL4782011

Oc1c(SC(F)(F)F)c(NS)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GABRB3 P28472 20/20 0.41
GABRA2 P47869 18/20 0.41
GABRB2 P47870 18/20 0.41
GABRP O00591 15/20 0.41
GABRD O14764 15/20 0.41
GABRA1 P14867 15/20 0.41
GABRB1 P18505 15/20 0.41
GABRG2 P18507 15/20 0.41
GABRA5 P31644 15/20 0.41
GABRA3 P34903 15/20 0.41
GABRA4 P48169 15/20 0.41
GABRE P78334 15/20 0.41
GABRA6 Q16445 15/20 0.41
GABRG1 Q8N1C3 15/20 0.41
GABRG3 Q99928 15/20 0.41
GABRQ Q9UN88 15/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4726875 0.81 GABRA2 (0.49) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL5993802 0.79 GABRP (0.49) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL3824608 0.78 GABRB3 (0.50) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL9196282 0.77 GABRB3 (0.53) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL4668752 0.76 GABRP (0.47) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL4669735 0.71 GABRB3 (0.50) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL10774181 0.70 GABRB3 (0.42) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL6055867 0.70 GABRP (0.56) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL6055871 0.69 GABRP (0.55) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL10425458 0.69 GABRB3 (0.47) GABRB3GABRA2GABRB2GABRPGABRD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1237873-B1 CONTROL OF ARTHROPODS IN ANIMALS MERIAL LTD (US) 2013-04-03 EP disclosed
US-7468381-B2 Control of arthropods in animals MERIAL, INC. 2008-12-23 US disclosed
US-20070078127-A1 Control of arthropods in animals AVENTIS CROPSCIENCE S.A. (FR) 2007-04-05 US disclosed
US-6992099-B2 Control of arthropods in animals AVENTIS CROPSCIENCE S.A. (FR) 2006-01-31 US disclosed
US-20060020013-A1 Control of arthropods in animals AVENTIS CROPSCIENCE S.A. (FR) 2006-01-26 US disclosed
US-20030176466-A1 Control of arthropods in animals AVENTIS CROPSCIENCE S.A. (FR) 2003-09-18 US disclosed
US-6569886-B2 Control of arthropods in animals AVENTIS CROPSCIENCE S.A. (FR) 2003-05-27 US disclosed
EP-1237873-A2 CONTROL OF ARTHROPODS IN ANIMALS Bayer CropScience S.A. (FR) 2002-09-11 EP disclosed
US-20020111352-A1 Control of arthropods in animals MERIAL, INC. 2002-08-15 US disclosed
WO-2001040195-A2 CONTROL OF ARTHROPODS IN ANIMALS AVENTIS CROPSCIENCE S.A. (FR) 2001-06-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020111352-A1 Control of arthropods in animals CTRL, CYP3A43, PON1 GABRB3 1089/4885GABRA2 1597/4885GABRB2 1438/4885
US-20030176466-A1 Control of arthropods in animals CTRL, CYP3A43, PON1 GABRB3 1089/4885GABRA2 1597/4885GABRB2 1438/4885
US-20070078127-A1 Control of arthropods in animals CTRL, CYP3A43, PON1 GABRB3 1089/4885GABRA2 1597/4885GABRB2 1438/4885
US-20060020013-A1 Control of arthropods in animals CTRL, CYP3A43, PON1 GABRB3 1089/4885GABRA2 1597/4885GABRB2 1438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.