Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 5/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 8/20 | 0.34 |
| ▸ | BRAF | P15056 | 8/20 | 0.34 |
| ▸ | RORC | P51449 | 4/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782033 | 0.91 | NR1I2 (0.35) | TEKNR1I2GPR119 | |
| SCHEMBL4781611 | 0.87 | TEK (0.39) | TEKNR1I2BRAFRORC | |
| SCHEMBL14293386 | 0.86 | TEK (0.43) | TEKNR1I2RAF1BRAF | |
| SCHEMBL4780719 | 0.85 | TEK (0.39) | TEKNR1I2RAF1BRAFRORC | |
| SCHEMBL4780202 | 0.84 | TEK (0.42) | TEKNR1I2RAF1BRAF | |
| SCHEMBL4783260 | 0.84 | MAPK14 (0.31) | NR1I2RAF1BRAF | |
| SCHEMBL4779210 | 0.84 | TEK (0.41) | TEKNR1I2RAF1BRAF | |
| SCHEMBL4783842 | 0.83 | TEK (0.38) | TEKNR1I2 | |
| SCHEMBL4782957 | 0.83 | BRAF (0.42) | TEKBRAF | |
| SCHEMBL4782191 | 0.82 | MEN1 (0.47) | TEKNR1I2RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |