Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 10/20 | 0.43 |
| ▸ | CA1 | P00915 | 10/20 | 0.43 |
| ▸ | CA2 | P00918 | 10/20 | 0.43 |
| ▸ | CA4 | P22748 | 10/20 | 0.43 |
| ▸ | CA7 | P43166 | 10/20 | 0.43 |
| ▸ | CA9 | Q16790 | 10/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18890179 | 0.86 | GLS (0.53) | CA12CA1CA2CA4CA7 | |
| SCHEMBL18890135 | 0.84 | GLS (0.51) | CA12CA1CA2CA4CA7 | |
| SCHEMBL15379128 | 0.84 | LMNA (0.60) | TRPV1CA12CA1CA2CA4 | |
| SCHEMBL18920480 | 0.84 | LMNA (0.60) | TRPV1CA12CA1CA2CA4 | |
| SCHEMBL23387371 | 0.81 | CA12 (0.52) | TRPV1TRPM8CA12CA1CA2 | |
| SCHEMBL23387372 | 0.81 | CA12 (0.52) | TRPV1TRPM8CA12CA1CA2 | |
| SCHEMBL954298 | 0.80 | CA12 (0.44) | TRPV1TRPM8CA12CA1CA2 | |
| SCHEMBL15205294 | 0.80 | TRPV1 (0.50) | TRPV1TRPM8CA12CA1CA2 | |
| SCHEMBL997974 | 0.80 | TRPV1 (0.50) | TRPV1TRPM8CA12CA1CA2 | |
| SCHEMBL15206576 | 0.80 | TRPV1 (0.50) | TRPV1TRPM8CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041090-A1 | MALANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONIST PYRIDINONES | PFIZER LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |