Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 6/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781660 | 0.81 | GLS (0.41) | GLS | |
| SCHEMBL22247229 | 0.76 | GLA (0.40) | SMYD3GLAMAPK1ALDH1A1LMNA | |
| SCHEMBL21206316 | 0.71 | SMYD3 (0.40) | SMYD3GLSCYP2C19GLAMAPK1 | |
| SCHEMBL24125043 | 0.70 | SMYD3 (0.37) | SMYD3GLSCYP2C19GLAMAPK1 | |
| SCHEMBL8931483 | 0.70 | HRH4 (0.41) | GLAALDH1A1LMNA | |
| SCHEMBL24621692 | 0.68 | TSHR (0.40) | SMYD3GLAMAPK1ALDH1A1LMNA | |
| SCHEMBL25447017 | 0.68 | GLS (0.38) | SMYD3GLSCYP2C19GLAMAPK1 | |
| SCHEMBL11910527 | 0.68 | SRC (0.41) | GLAMAPK1ALDH1A1LMNACNR2 | |
| SCHEMBL31720484 | 0.68 | SMYD3 (0.41) | SMYD3GLSKLKB1GLAMAPK1 | |
| SCHEMBL7963203 | 0.67 | NOTUM (0.49) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |