Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.31 |
| ▸ | SELE | P16581 | 1/20 | 0.30 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31426236 | 0.82 | LMNA (0.35) | LMNACYP3A4MAPTAPEX1MAPK1 | |
| SCHEMBL1774726 | 0.80 | F2RL3 (0.35) | LMNACYP3A4MAPTAPEX1MAPK1 | |
| SCHEMBL441078 | 0.80 | ALDH1A1 (0.39) | LMNACYP3A4MAPTAPEX1MAPK1 | |
| SCHEMBL30456808 | 0.80 | F2RL3 (0.35) | LMNACYP3A4MAPTAPEX1MAPK1 | |
| SCHEMBL23088271 | 0.77 | CYP2A6 (0.49) | LMNACYP3A4MAPTAPEX1MAPK1 | |
| SCHEMBL29792650 | 0.77 | CYP2A6 (0.49) | LMNACYP3A4MAPTAPEX1MAPK1 | |
| SCHEMBL7053747 | 0.76 | LMNA (0.32) | LMNACYP3A4MAPTAPEX1MAPK1 | |
| SCHEMBL23088293 | 0.76 | CYP2A6 (0.41) | LMNACYP3A4MAPTAPEX1MAPK1 | |
| SCHEMBL20659860 | 0.76 | SELE (0.54) | LMNACYP3A4MAPTF2RL3SELE | |
| SCHEMBL14275266 | 0.76 | LMNA (0.32) | LMNACYP3A4MAPTAPEX1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675856-A1 | COMPOUNDS AND METHODS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR | Corvus Pharmaceuticals, Inc. (US) | 2020-07-08 | — | — | EP | disclosed |
| EP-3507276-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | Gilead Sciences, Inc. (US) | 2019-07-10 | — | — | EP | disclosed |
| WO-2019046784-A1 | COMPOUNDS AND METHODS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR | CORVUS PHARMACEUTICALS, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2018045144-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2018-03-08 | — | — | WO | disclosed |
| EP-2132211-A2 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | Ardea Biosciences, Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008058285-A2 | 4-CYANOPHENYLAMINO-SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-05-15 | — | — | WO | disclosed |