Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 7/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779959 | 0.84 | KDM4E (0.50) | RAB9AKDM4EMAPTNPC1MEN1 | |
| SCHEMBL15649768 | 0.83 | ITK (0.35) | RAB9AKDM4EMAPTNPC1MEN1 | |
| SCHEMBL15649163 | 0.81 | ITK (0.34) | ITKAURKAAURKBKDRCHEK1 | |
| SCHEMBL15649162 | 0.80 | LOXL2 (0.39) | ITKAURKAAURKBKDRCHEK1 | |
| SCHEMBL4779384 | 0.80 | CYP19A1 (0.39) | RAB9AKDM4EMAPTNPC1MEN1 | |
| SCHEMBL4779388 | 0.80 | CYP19A1 (0.39) | RAB9AKDM4EMAPTNPC1MEN1 | |
| SCHEMBL15649168 | 0.80 | EHMT2 (0.38) | RAB9AKDM4EMAPTMEN1KMT2A | |
| SCHEMBL537355 | 0.76 | RAB9A (0.61) | RAB9AKDM4EMAPTNPC1MEN1 | |
| SCHEMBL15648544 | 0.76 | ITK (0.33) | ALDH1A1SMN1; SMN2ITKAURKAAURKB | |
| SCHEMBL15649653 | 0.74 | ITK (0.40) | ITKKDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |