Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 3/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782507 | 0.84 | RAB9A (0.47) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL15649168 | 0.80 | EHMT2 (0.38) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL15649768 | 0.79 | ITK (0.35) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL15649163 | 0.77 | ITK (0.34) | ITKAURKAKDRCA2PDGFRB | |
| SCHEMBL15649162 | 0.76 | LOXL2 (0.39) | ITKAURKAKDRPDGFRBLOXL2 | |
| SCHEMBL4782144 | 0.74 | SLC40A1 (0.52) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL15058354 | 0.74 | KDM4E (0.72) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL15648544 | 0.72 | ITK (0.33) | ITKAURKAKDRPDGFRBCCNA2 | |
| SCHEMBL28696935 | 0.71 | KDM4E (0.52) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL15649653 | 0.70 | ITK (0.40) | ITKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025526-A1 | INDOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |