Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 17/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 6/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.42 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.42 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28268477 | 0.87 | EGFR (0.43) | PLA2G10SLC9A1KMT2AALDH1A1LMNA | |
| SCHEMBL27798472 | 0.82 | EGFR (0.41) | KMT2AALDH1A1LMNAMAPTPKM | |
| SCHEMBL14306651 | 0.77 | PLA2G2A (0.71) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL1253404 | 0.76 | EGFR (0.42) | SLC9A1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL30960119 | 0.76 | PLA2G2A (0.62) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| Hydrochloric Acid SCHEMBL1504224 | 0.75 | EGFR (0.41) | SLC9A1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL17699703 | 0.72 | EGFR (0.41) | SLC9A1KMT2AALDH1A1MAPTPKM | |
| SCHEMBL5799161 | 0.71 | EGFR (0.41) | KMT2AALDH1A1LMNAMAPTPKM | |
| SCHEMBL28434877 | 0.71 | SLC9A1 (0.41) | SLC9A1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL13727308 | 0.71 | CD44 (0.40) | SLC9A1ALDH1A1LMNAMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3024926-A1 | GENERATING DEFINITIVE ENDODERM AND PANCREATIC PROGENITOR CELLS | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone (US) | 2016-06-01 | — | — | EP | disclosed |
| WO-2015013653-A1 | GENERATING DEFINITIVE ENDODERM AND PANCREATIC PROGENITOR CELLS | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE (US) | 2015-01-29 | — | — | WO | disclosed |
| WO-2008013823-A2 | CO-CRYSTALS OF (2R-TRANS)-6-CHLORO-5-[[4-[(4-FLUOROPHENYL)METHYL]-2,5-DIMETHYL-1-PIPERAZINYL]CARBONYL]-N,N,1-TRIMETHYL-ALPHA-OXO-1H-INDOLE-3-ACETAMIDE | SCIOS INC. (US) | 2008-01-31 | — | — | WO | disclosed |