Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | SFRP1 | Q8N474 | 14/20 | 0.43 |
| ▸ | WNT3 | P56703 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.38 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781542 | 0.90 | PTGDR2 (0.44) | NR1H2SFRP1WNT3PTGDR2ALDH1A1 | |
| SCHEMBL4783485 | 0.85 | NR1H2 (0.54) | NR1H2SFRP1WNT3MEN1ALDH1A1 | |
| SCHEMBL4784216 | 0.80 | NR1H2 (0.49) | NR1H2SFRP1WNT3MEN1ALDH1A1 | |
| SCHEMBL4784211 | 0.79 | NR1H2 (0.48) | NR1H2SFRP1WNT3MEN1KMT2A | |
| SCHEMBL4783187 | 0.77 | NR1H2 (0.44) | NR1H2SFRP1PTGDR2 | |
| SCHEMBL4907973 | 0.76 | NR1H2 (0.46) | NR1H2HTR1AHTR7 | |
| SCHEMBL4782504 | 0.76 | NR1H2 (0.55) | NR1H2SFRP1WNT3 | |
| SCHEMBL4781127 | 0.75 | NR1H2 (0.51) | NR1H2SFRP1WNT3 | |
| SCHEMBL4733742 | 0.75 | NR1H2 (0.55) | NR1H2SFRP1WNT3MEN1ALDH1A1 | |
| SCHEMBL4784882 | 0.75 | NR1H2 (0.53) | NR1H2SFRP1WNT3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |