Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.54 |
| ▸ | SFRP1 | Q8N474 | 11/20 | 0.45 |
| ▸ | WNT3 | P56703 | 4/20 | 0.42 |
| ▸ | AGER | Q15109 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | APOB | P04114 | 2/20 | 0.41 |
| ▸ | MTTP | P55157 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907973 | 0.91 | NR1H2 (0.46) | NR1H2ALOX15TSHRHSD17B10ADRB1 | |
| SCHEMBL4637035 | 0.88 | SFRP1 (0.62) | SFRP1WNT3 | |
| SCHEMBL4783187 | 0.87 | NR1H2 (0.44) | NR1H2SFRP1AGERALOX15TSHR | |
| SCHEMBL4782872 | 0.85 | NR1H2 (0.49) | NR1H2SFRP1WNT3MEN1ALDH1A1 | |
| SCHEMBL4781822 | 0.85 | NR1H2 (0.42) | NR1H2SFRP1WNT3AGERALOX15 | |
| SCHEMBL4781448 | 0.83 | NR1H2 (0.57) | NR1H2SFRP1WNT3MEN1KMT2A | |
| SCHEMBL10391218 | 0.82 | APOB (0.52) | NR1H2ALOX15TSHRHSD17B10ADRB1 | |
| SCHEMBL4781466 | 0.82 | NR1H2 (0.47) | NR1H2SFRP1APOBMTTP | |
| SCHEMBL4733742 | 0.82 | NR1H2 (0.55) | NR1H2SFRP1WNT3APOBMTTP | |
| SCHEMBL4781127 | 0.82 | NR1H2 (0.51) | NR1H2SFRP1WNT3APOBMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |