Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.57 |
| ▸ | HTR2C | P28335 | 9/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784011 | 0.87 | HTR2A (0.66) | HTR2AHTR2CKCNH2RBP4KDM4E | |
| SCHEMBL4784514 | 0.85 | HTR2A (0.58) | HTR2AHTR2CKCNH2KDM4EALDH1A1 | |
| SCHEMBL4782758 | 0.85 | HTR2A (0.60) | HTR2AHTR2CKCNH2RBP4KDM4E | |
| SCHEMBL4783543 | 0.83 | HTR2A (0.58) | HTR2AHTR2CKCNH2KDM4EALDH1A1 | |
| SCHEMBL4781251 | 0.80 | HTR2A (0.52) | HTR2AHTR2CKCNH2KDM4EALDH1A1 | |
| SCHEMBL4784747 | 0.80 | HTR2A (0.52) | HTR2AHTR2CKCNH2KDM4EALDH1A1 | |
| SCHEMBL14205207 | 0.79 | HTR2A (0.56) | HTR2AHTR2CKCNH2ALDH1A1TSHR | |
| SCHEMBL4781280 | 0.76 | HTR2A (0.66) | HTR2AHTR2CKCNH2ALDH1A1TSHR | |
| SCHEMBL4780094 | 0.75 | HTR2A (0.67) | HTR2AHTR2CKCNH2ALDH1A1 | |
| SCHEMBL4783355 | 0.74 | HTR2A (0.60) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |