SCHEMBL4784747

SCHEMBL4784747

O=C(CN1CCN(C(=O)c2nn(S(=O)(=O)c3ccccc3)c3ccccc23)CC1)c1ccc(F)cc1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 16/20 0.52
HTR2C P28335 10/20 0.52
KCNH2 Q12809 3/20 0.51
ALDH1A1 P00352 2/20 0.44
GAA P10253 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
PKM P14618 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
CYP2C19 P33261 1/20 0.44
KDM4E B2RXH2 1/20 0.44
MAPT P10636 1/20 0.44
RECQL P46063 1/20 0.44
PTGS1 P23219 1/20 0.44
PTGS2 P35354 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4784514 0.83 HTR2A (0.58) HTR2AHTR2CKCNH2ALDH1A1TSHR
SCHEMBL4784011 0.82 HTR2A (0.66) HTR2AHTR2CKCNH2ALDH1A1TSHR
SCHEMBL4782758 0.81 HTR2A (0.60) HTR2AHTR2CKCNH2ALDH1A1TSHR
SCHEMBL4783108 0.80 HTR2A (0.57) HTR2AHTR2CKCNH2ALDH1A1TSHR
SCHEMBL4783543 0.79 HTR2A (0.58) HTR2AHTR2CKCNH2ALDH1A1TSHR
SCHEMBL4781251 0.78 HTR2A (0.52) HTR2AHTR2CKCNH2ALDH1A1TSHR
SCHEMBL14205207 0.77 HTR2A (0.56) HTR2AHTR2CKCNH2ALDH1A1TSHR
SCHEMBL4781280 0.74 HTR2A (0.66) HTR2AHTR2CKCNH2ALDH1A1TSHR
SCHEMBL4780094 0.71 HTR2A (0.67) HTR2AHTR2CKCNH2ALDH1A1
SCHEMBL4783355 0.70 HTR2A (0.60) HTR2AHTR2CKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008054748-A2 INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2008-05-08 WO disclosed
WO-2008054748-A2 INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2008-05-08 WO disclosed