Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 13/20 | 0.64 |
| ▸ | DRD2 | P14416 | 8/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431212 | 0.78 | DRD4 (1.00) | DRD4DRD2 | |
| SCHEMBL8435196 | 0.77 | DRD4 (1.00) | DRD4DRD2CYP19A1 | |
| SCHEMBL8432504 | 0.76 | DRD4 (0.79) | DRD4DRD2KCNH2MCHR2MCHR1 | |
| SCHEMBL6333889 | 0.73 | MCHR1 (1.00) | KCNH2MCHR2MCHR1 | |
| SCHEMBL16582078 | 0.73 | ALDH1A1 (0.64) | KCNH2KDM4EALDH1A1 | |
| SCHEMBL5368002 | 0.73 | GAA (0.69) | DRD4DRD2KDM4EALDH1A1 | |
| SCHEMBL12660139 | 0.73 | KDM4E (0.64) | KCNH2KDM4EALDH1A1 | |
| SCHEMBL8431223 | 0.72 | DRD4 (1.00) | DRD4DRD2KDM4EALDH1A1 | |
| SCHEMBL26133908 | 0.72 | ICAM1 (0.52) | KCNH2KDM4EALDH1A1 | |
| SCHEMBL14174789 | 0.72 | ALDH1A1 (0.67) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045564-A2 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2008-04-17 | — | — | WO | claimed |