Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 17/20 | 0.79 |
| ▸ | DRD2 | P14416 | 11/20 | 0.79 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431212 | 0.88 | DRD4 (1.00) | DRD4DRD2MAOB | |
| SCHEMBL8431572 | 0.81 | DRD4 (1.00) | DRD4DRD2DRD3 | |
| SCHEMBL17432875 | 0.78 | MEN1 (0.61) | DRD4DRD2DRD3KCNH2 | |
| SCHEMBL4783447 | 0.76 | DRD4 (0.64) | DRD4DRD2CYP19A1KCNH2MCHR2 | |
| SCHEMBL8435196 | 0.75 | DRD4 (1.00) | DRD4DRD2CYP19A1MAOB | |
| SCHEMBL5753083 | 0.75 | DRD2 (0.53) | DRD4DRD2DRD3KCNH2MCHR2 | |
| SCHEMBL8431470 | 0.74 | DRD4 (1.00) | DRD4DRD2 | |
| SCHEMBL8431350 | 0.73 | DRD4 (1.00) | DRD4DRD2DRD3 | |
| SCHEMBL8431263 | 0.72 | DRD4 (1.00) | DRD4DRD2 | |
| SCHEMBL29869413 | 0.72 | MEN1 (0.54) | DRD4DRD2DRD3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922719-A | 4-AROMATIC-SUBSTITUTED-PIPERAZIN-1-YLMETHYLCHROMEN-2-ONES | WARNER-LAMBERT COMPANY (US) | 1999-07-13 | — | — | US | disclosed |