Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783408 | 0.87 | HTR6 (0.47) | HTR6CYP3A4CYP2D6LMNAMEN1 | |
| SCHEMBL4784316 | 0.84 | HTR6 (0.46) | HTR6CYP3A4CYP2D6LMNAMEN1 | |
| SCHEMBL4782100 | 0.84 | HTR6 (0.47) | HTR6CYP3A4CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL4783465 | 0.82 | HTR6 (0.51) | HTR6CYP3A4CYP2D6LMNAMEN1 | |
| SCHEMBL4781382 | 0.81 | HTR6 (0.43) | HTR6CYP3A4CYP2D6LMNAMEN1 | |
| SCHEMBL4781323 | 0.81 | HTR6 (0.43) | HTR6CYP3A4CYP2D6LMNAMEN1 | |
| SCHEMBL4781303 | 0.81 | HTR6 (0.43) | HTR6CYP3A4CYP2D6LMNAMEN1 | |
| SCHEMBL22864566 | 0.79 | HTR6 (0.60) | HTR6CYP3A4CYP2D6LMNAMEN1 | |
| SCHEMBL29651295 | 0.79 | HTR6 (0.60) | HTR6CYP3A4CYP2D6LMNAMEN1 | |
| SCHEMBL4783073 | 0.78 | HTR6 (0.45) | HTR6CYP3A4CYP2D6LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8821850-B2 | Protein-polymer-drug conjugates | MERSANA THERAPEUTICS, INC. (US) | 2014-09-02 | — | — | US | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |