SCHEMBL4783559

SCHEMBL4783559

Cc1cn([C@@H]2O[C@H](C(O)C(=O)c3ccccc3)[C@](O)(C(=O)c3ccccc3)[C@H]2F)c(=O)[nH]c1=O

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.40
TYMP P19971 1/20 0.38
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
ALB P02768 1/20 0.37
POLB P06746 1/20 0.37
ADRA1A P35348 1/20 0.37
BLM P54132 1/20 0.37
TK1 P04183 4/20 0.35
NT5M Q9NPB1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8816517 0.89
SCHEMBL8888860 0.82 RNASE1 (0.42) RNASE1TYMPALDH1A1LMNAALB
SCHEMBL7868482 0.82 LMNA (0.43) LMNA
SCHEMBL9223581 0.80 RNASE1 (0.44) RNASE1TYMPALDH1A1LMNAALB
SCHEMBL10643586 0.79 LMNA (0.41) TYMPALDH1A1LMNAALBPOLB
SCHEMBL749811 0.79 RNASE1 (0.38) RNASE1TYMPALDH1A1LMNAALB
SCHEMBL8595983 0.78 RNASE1 (0.39) RNASE1TYMPALDH1A1LMNAALB
SCHEMBL8771276 0.78 RNASE1 (0.39) RNASE1TYMPALDH1A1LMNAALB
SCHEMBL8612661 0.75 RNASE1 (0.44) RNASE1TYMPALDH1A1LMNAALB
SCHEMBL6297081 0.74 PYGM (0.35) RNASE1TYMPTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008069451-A1 IMPROVED PROCESS FOR THE PREPARATION OF CLEVUDINE AS ANTI-HBV AGENT BUKWANG PHARM CO., LTD. (KR) 2008-06-12 WO disclosed
EP-1373288-A1 PROCESS FOR THE PREPARATION OF 2'-HALO-BETA-L-ARABINOFURANOSYL NUCLEOSIDES Triangle Pharmaceuticals Inc. (US) 2004-01-02 EP disclosed
WO-2002079213-A1 PROCESS FOR THE PREPARATION OF 2'-HALO-$G(B)-L-ARABINOFURANOSYL NUCLEOSIDES TRIANGLE PHARMACEUTICALS, INC. (US) 2002-10-10 WO disclosed
WO-1999044646-A1 NOVEL IMAGING AGENTS AND METHODS FOR THE PREPARATION AND USE THEREOF UNIVERSITY ADVANCED BIO-IMAGING ASSOCIATES (US) 1999-09-10 WO disclosed