Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501379 | 0.91 | PRKCA (0.37) | PRKCIIKBKB | |
| SCHEMBL2608414 | 0.78 | PRKCI (0.53) | PRKCIACMSDCHRNB4CHRNA3CHRNA7 | |
| SCHEMBL4742321 | 0.74 | CYP1A2 (0.57) | RXRARXRB | |
| SCHEMBL12849369 | 0.74 | PRKCI (0.49) | PRKCIACMSDADAMTS4CHRNB4CHRNA3 | |
| SCHEMBL840466 | 0.73 | ESR1 (0.39) | KIF11 | |
| SCHEMBL501361 | 0.72 | ENPP2 (0.40) | — | |
| SCHEMBL4191589 | 0.72 | PRKCI (0.72) | PRKCIACMSDCHRNB4CHRNA3CHRNA7 | |
| SCHEMBL10269541 | 0.72 | PRKCI (0.53) | PRKCIACMSDRXRARXRBKIF11 | |
| SCHEMBL2854904 | 0.71 | KLF10 (0.42) | — | |
| SCHEMBL13761767 | 0.70 | PRKCI (0.56) | PRKCIACMSDADAMTS4RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033455-A2 | BIPHENYL AND HETEROARYL PHENYL DERIVATIVES AS PROTEIN TYROSINE PHOSPHATASES INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-03-20 | — | — | WO | disclosed |