Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27246689 | 0.83 | TDP1 (0.52) | MEN1KMT2ADRD2SIGMAR1TDP1 | |
| SCHEMBL3953782 | 0.83 | NPC1 (0.40) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL3387585 | 0.77 | DRD2 (0.47) | MEN1KMT2ADRD2SIGMAR1TDP1 | |
| SCHEMBL6675697 | 0.76 | DRD2 (0.46) | MEN1KMT2ADRD2SIGMAR1TDP1 | |
| SCHEMBL20386735 | 0.75 | DRD2 (0.48) | MAPTDRD2SIGMAR1 | |
| SCHEMBL1308684 | 0.75 | DRD2 (0.55) | DRD2SIGMAR1TDP1 | |
| SCHEMBL10374343 | 0.74 | PPARG (0.41) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL3388119 | 0.74 | DRD2 (0.44) | MEN1MAPTKMT2ALMNADRD2 | |
| SCHEMBL1467340 | 0.74 | NAAA (0.56) | ALDH1A1MEN1KMT2ALMNANPC1 | |
| SCHEMBL4782988 | 0.74 | CNR2 (0.47) | DRD2SIGMAR1TDP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067222-A1 | HETEROCYCLIC MODULATORS OF TGR5 | KALYPSYS, INC. (US) | 2008-06-05 | — | — | WO | disclosed |