Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783795 | 0.90 | KDM4E (0.44) | KDM4EHSD17B10GRM2METAP2METAP1 | |
| SCHEMBL1840712 | 0.75 | ALDH1A1 (0.49) | KDM4EHSD17B10GRM2TP53CYP1A2 | |
| SCHEMBL26606768 | 0.74 | THRB (0.43) | KDM4EGRM2RAB9A | |
| SCHEMBL26606785 | 0.73 | IKBKB (0.53) | KDM4EHSD17B10NPC1TP53CYP1A2 | |
| SCHEMBL18670685 | 0.71 | EEF2K (0.39) | RAB9A | |
| SCHEMBL16038368 | 0.70 | KDM4E (0.46) | KDM4EHSD17B10METAP2METAP1TACR3 | |
| Formamide SCHEMBL28891685 | 0.70 | ALDH1A1 (0.44) | KDM4EHSD17B10GRM2TP53CYP1A2 | |
| SCHEMBL18670688 | 0.68 | EEF2K (0.35) | KDM4EHSD17B10RAB9A | |
| SCHEMBL9193444 | 0.68 | MAPT (0.49) | KDM4EHSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL14930803 | 0.67 | CYP1A2 (0.50) | KDM4EHSD17B10GRM2METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |