Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.68 |
| ▸ | DRD2 | P14416 | 2/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782835 | 0.87 | HTR2A (0.64) | HTR2ADRD2HTR2CRBP4MEN1 | |
| SCHEMBL4848833 | 0.85 | HTR2A (0.63) | HTR2ADRD2KCNH2HTR2CRBP4 | |
| SCHEMBL14205784 | 0.83 | HTR2A (0.63) | HTR2ADRD2KCNH2HTR2CRBP4 | |
| SCHEMBL27249713 | 0.83 | HTR2A (0.66) | HTR2ADRD2RBP4MEN1KMT2A | |
| SCHEMBL4784635 | 0.81 | HTR2A (0.67) | HTR2ADRD2KCNH2HTR2C | |
| SCHEMBL4781253 | 0.80 | HTR2A (0.61) | HTR2ADRD2KCNH2HTR2CRBP4 | |
| SCHEMBL27249712 | 0.78 | DRD2 (0.60) | HTR2ADRD2RBP4MEN1KMT2A | |
| SCHEMBL29573031 | 0.78 | HTR2A (0.77) | HTR2AKCNH2HTR2C | |
| SCHEMBL3143833 | 0.78 | HTR2A (0.77) | HTR2AKCNH2HTR2C | |
| SCHEMBL4780625 | 0.78 | HTR2A (0.64) | HTR2ADRD2KCNH2HTR2CRBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |