Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539543 | 0.84 | SMN1; SMN2 (0.41) | NPC1RAB9AALDH1A1MAPK1HPGD | |
| SCHEMBL8536874 | 0.81 | CSNK1A1 (0.45) | NPC1ALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL8538107 | 0.78 | MAPT (0.43) | NPC1RAB9AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL3631532 | 0.75 | RAB9A (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2NISCH | |
| SCHEMBL8541400 | 0.75 | MC4R (0.37) | NPC1RAB9AALDH1A1MAPK1HPGD | |
| SCHEMBL8539541 | 0.74 | CYP1A2 (0.43) | NPC1RAB9AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8542466 | 0.74 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1MAPK1CYP1A2 | |
| SCHEMBL31429694 | 0.74 | IDO1 (0.51) | NPC1RAB9AALDH1A1CYP3A4CYP19A1 | |
| SCHEMBL8537063 | 0.72 | NR4A2 (0.43) | NPC1RAB9AALDH1A1MAPK1HPGD | |
| SCHEMBL29084865 | 0.72 | IDO1 (0.58) | NPC1RAB9AALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |