Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | APOB | P04114 | 1/20 | 0.36 |
| ▸ | MTTP | P55157 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783415 | 0.85 | NR1H2 (0.41) | GRIA2NR1H2CNR2 | |
| SCHEMBL4783419 | 0.85 | NR1H2 (0.43) | GRIA2NR1H2 | |
| SCHEMBL4784502 | 0.85 | TRPV4 (0.45) | TRPV4GRIA2NR1H2CNR2SFRP1 | |
| SCHEMBL4785061 | 0.82 | NR1H2 (0.37) | GRIA2NR1H2CNR2SFRP1 | |
| SCHEMBL4733733 | 0.79 | SFRP1 (0.54) | CNR2SFRP1 | |
| SCHEMBL4781822 | 0.78 | NR1H2 (0.42) | GRIA2NR1H2SFRP1IDH1 | |
| SCHEMBL4782721 | 0.78 | NR1H2 (0.41) | GRIA2NR1H2CNR2SFRP1 | |
| SCHEMBL4731294 | 0.75 | SFRP1 (0.55) | TRPV4CNR2SFRP1SLC22A12 | |
| SCHEMBL4794680 | 0.72 | NR1H2 (0.46) | GRIA2NR1H2CNR2SFRP1PNMT | |
| SCHEMBL4733149 | 0.72 | SFRP1 (0.48) | SFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |